Dr Jarrahi laboratory

 

I pursue my subjects of interests in neurophysiology in three subjects and in three laboratores, which were established in 2005 as a part of physiology research center.

 

Neurophysiology Simulation (Action potential, NCV and EMG) Research Lab

 

The neurophysiology simulation research lab is engaged with electromyography (EMG), nerve conduction velocity (NCV) and Action potential experiments.

EMG involves inserting a fine needle into a muscle to compare the amount of electrical activity present when muscles are at rest and when they contract. EMG tests can help differentiate between muscle and nerve disorders.

NCV tests can precisely measure the degree of damage in larger nerve fibers, revealing whether symptoms are being caused by degeneration of the myelin sheath or the axon. During this test, a probe electrically stimulates a nerve fiber, which responds by generating its own electrical impulse. An electrode placed further along the nerve’s pathway measures the speed of impulse transmission along the axon. Slow transmission rates and impulse blockage tend to indicate damage to the myelin sheath, while a reduction in the strength of impulses is a sign of axonal degeneration.

The primary goal of our research is to identify new drugs for treating some kinds of neuropathies. One of the subjects of our investigations is:

The effects of progesterone on neuropathic pain responses in an experimental animal model for peripheral neuropathy in the rat: a behavioral and electrophysiological study.

 

Wound healing Lab

 

Wound healing, is the body's natural process of regenerating dermal and epidermal tissue. Plants and their extracts have immense potential for treatment of wounds.

Our researchlabhas been focused on treatment of wounds by medicinal plants and folk remedy. Animal models of wounds can be great help for research of therapeutic strategies. The wound healing lab has facilities such as: Surgery suite – small animals (guinea pigs – Rat – and rabbit), general and local anesthesia, individual housing, planimetry analysis for measuring wound contraction, histological measurements of wound healing and biomechanical characteristics of wound (in related departments).

 

Motor Coordination Lab

 

The Motor Coordination Laboratory is designed for the study of neurophysiological and biomechanical factors in rat motor control. The laboratory is equipped with a variety of equipments such as rotarod, beam walking and a new designed apparatus. The rotarod test is used to assess motor coordination and balance in rodents. Rats have to keep their balance on a rotating rod. It measures the time (latency) which takes the rat to fall off the rod rotating at different speeds or under continuous acceleration (e.g. from 4 to 40rpm). We have designed a new apparatus for the study of motor Coordination in rat considering:

·        Comparison of beam walking with and without our new designed apparatus to measure the fine motor control

·        Testing the new designed apparatus for motor skills memory

 

At the meantime, there are few vacancies for Master’s student at my lab.

 

M. Jarrahi, PhD.

Assistant Prof. in Neuroscience

Email: jarrahi44@yahoo.com